The brain needs interleukin - 6 ( IL - 6 ) to maintain a “ healthy ” energy balance 1 2 Focus on “ IL - 6 ameliorates defective leptin sensitivity in DIO ventromedial hypothalamic 3
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چکیده
The brain needs interleukin-6 (IL-6) to maintain a “healthy” energy balance 1 2 Focus on “IL-6 ameliorates defective leptin sensitivity in DIO ventromedial hypothalamic 3 nucleus neurons” 4 5 6 Thomas A. Lutz 7 Institute of Veterinary Physiology and 8 Center of Integrative Human Physiology (ZIHP) 9 University of Zurich 10 Winterthurerstrasse 260 11 8057 Zurich 12 Switzerland 13 14 phone + 41 – 44 – 635 8808 15 fax +41 – 44 – 635 8932 16 e-mail [email protected] 17 18 running title: IL-6 and metabolic control 19 key words: IL-6; cytokines; hypothalamus; leptin; amylin; VMH 20 21 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (October 12, 2016). doi:10.1152/ajpregu.00426.2016
منابع مشابه
The brain needs interleukin-6 (IL-6) to maintain a "healthy" energy balance. Focus on "IL-6 ameliorates defective leptin sensitivity in DIO ventromedial hypothalamic nucleus neurons".
LARSEN AND COLLEAGUES’ (13) recent paper provides an important piece of evidence that leptin sensitivity is under dynamic control and that interleukin-6 (IL-6) is an important player in this control system. IL-6 may increase leptin sensitivity in the ventromedial hypothalamic nucleus (VMN) at least in part by modifying leptin receptor transport to the cell membrane in VMN neurons. This will hel...
متن کاملIL-6 ameliorates defective leptin sensitivity in DIO ventromedial hypothalamic nucleus neurons.
Rats selectively bred to develop diet-induced obesity (DIO) have an early onset reduction in the sensitivity of their ventromedial hypothalamic nucleus (VMN) neurons to leptin compared with diet-resistant (DR) rats. This reduced sensitivity includes decreased leptin receptor (Lepr-b) mRNA expression, leptin receptor binding, leptin-induced phosphorylation of STAT3 (pSTAT3), and impaired leptin ...
متن کاملBrain IL-6--Where Amylin and GLP-1 Antiobesity Signaling Congregate.
A prerequisite for the homeostatic control of fat mass is the existence of peripheral hormones that, together with nervous afferents, signal the state of energy balance to adipostatic circuits in the brain. It is assumed that the effects of these signals are mediated, at least in part, by changes in key neurotransmitters, especially those located in the hypothalamus. It has been known for many ...
متن کاملAmylin-Induced Central IL-6 Production Enhances Ventromedial Hypothalamic Leptin Signaling
Amylin acts acutely via the area postrema to reduce food intake and body weight, but it also interacts with leptin over longer periods of time, possibly via the ventromedial hypothalamus (VMH), to increase leptin signaling and phosphorylation of STAT3. We postulated that amylin enhances VMH leptin signaling by inducing interleukin (IL)-6, which then interacts with its gp130 receptor to activate...
متن کاملObesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset.
Rats selectively bred to develop diet-induced obesity (DIO) were compared with those bred to be diet resistant (DR) on a 31% fat high-energy diet with regard to their central leptin signaling and blood-brain barrier (BBB) transport. Peripheral leptin injection (15 mg/kg ip) into lean 4- to 5-wk-old rats produced 54% less anorexia in DIO than DR rats. DIO rats also had 21, 63, and 64% less lepti...
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تاریخ انتشار 2016